Goals from Neil Mellor and two from Chris Brown saw the Lilywhites to a victory on the seaside, with Adam Hammill socring for the home side.
Blackpool took the lead inside 10 minutes but a second half fight back for North End saw them to the three points.
PNE Starting XI: Lonergan, Jones, St. Ledger, Wayne Brown, Davidson, Sedgwick, McKenna, Chaplow, Wallace, Chris Brown, Mellor (Elliott 89).Subs Not Used: Mawene, Nicholson, Parkin, Neal.
Blackpool Starting XI: Rachubka, Barker, Evatt, Edwards, Camara, Taylor-Fletcher (Hendrie 74), Southern (McPhee 74), Jorgensen, Hammill, Burgess, Gow (Kabba 60).Subs Not Used: Broomes, Fox.