North End have taken just one point from a possible nine but a win at Bramall Lane would firmly put them back on course for a top six spot.
Unfortunately for the Lilywhties, they do not historically travel well to United, but this weekend is a chance to change that.
One time that they did enjoy their trip to Yokrshire was in 2018, as Alex Neil’s side won 1-0, with Alan Browne scoring the only goal of the game.
The win meant North End’s hopes of a play-off place went to the final day of the season (sound familiar?) although they ended up finishing seventh.
1. Having a minute
Preston North End's Josh Harrop lies down Photo: CameraSport - Chris Vaughan
2. Browne gets the goal
Preston North End's Alan Browne scores the opening goal Photo: CameraSport - Chris Vaughan
3. Here comes the kitchen sink...
PNE hold out against late pressure from Sheffield United - which included them sending their keeper up for a corner Photo: National World
4. Clarkey has a word
Preston North End's Tom Clarke appeals after his effort was ruled out Photo: CameraSport - Chris Vaughan